Antagonism of Colistin-sulphonamide Synergism by para-Aminobenzoic Acid
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چکیده
منابع مشابه
Para-aminobenzoic Acid Production by Staphylococci
1. Strains of staphylococci produce diazotizable materials which can be converted to a dye, and the intensity of the color reaction can be quantitated in the same manner as p-aminobenzoic acid. The sulfonamide-resistant strains which we have studied produce more diazotizable substance than non-resistant strains. 2. The development of a color by the diazotizable substance can be inhibited by exp...
متن کاملThe replacement of para-aminobenzoic acid by methionine in the growth of a Neurospora mutant.
Present knowledge of the function of para-aminobenzoic acid (PABA) has been derived almost exclusively from sulfanilamide (SAN) inhibition studies. Shive and Roberts (1946) have advanced the hypothesis that PABA is catalytically active in the synthesis of a number of metabolic products in Escherichia coli and that the enzyme systems concerned in their production are differentially sensitive to ...
متن کاملObservations on the Inhibition of Sulfonamide Action by Para-aminobenzoic Acid.
Considerable interest has been aroused recently in the investigation of substances which inhibit the action of the sulfonamide drugs. Lockwood (1) showed that peptones inhibit the action of sulfanilamide on streptococci. Stamp (2) isolated certain fractions of streptococci, and Green (3) isolated fractions of brucella, which have similar activity with respect to the corresponding organisms. Wes...
متن کاملThe Isolation and Identification of Para-aminobenzoic Acid Produced by Staphylococci Resistant to Sulfonamide
Previous studies have shown that when Staphylococcus aureus becomes resistant to sulfonamides, an antisulfonamide substance is produced in the growth medium. Although these studies suggested that the substance was p-aminobenzoic acid (PABA), isolation and positive identification were not achieved. Because of the importance of these observations, unequivocal identification of the product was att...
متن کاملCharacterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis.
The pab genes for para-aminobenzoic acid (pABA) biosynthesis in Lactococcus lactis were identified and characterized. In L. lactis NZ9000, only two of the three genes needed for pABA production were initially found. No gene coding for 4-amino-4-deoxychorismate lyase (pabC) was initially annotated, but detailed analysis revealed that pabC was fused with the 3' end of the gene coding for chorisma...
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ژورنال
عنوان ژورنال: Nature
سال: 1966
ISSN: 0028-0836,1476-4687
DOI: 10.1038/2091357a0